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Dengue Virus
Dengue fever is typically transmitted through mosquito bites and is an illness caused by the Dengue virus. Its transmission is associated with mosquitoes being more active in warm and humid climate conditions.
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Dengue Virus
Dengue fever virus is a pathogen caused by the Dengue virus, belonging to the Flaviviridae family. The virus has four distinct serotypes, namely DEN-1, DEN-2, DEN-3, and DEN-4.
Four main serotypes:
DENV-1: A serotype of the Dengue fever virus, capable of causing Dengue fever infection. Individuals infected with DENV-1 may exhibit typical symptoms of Dengue fever, including fever, headache, muscle and joint pain, and more.
DENV-2: Another serotype that can cause Dengue fever. Individuals infected with DENV-2 may experience similar symptoms, including fever, headache, and rash. Severe infections may lead to hemorrhagic fever.
DENV-3: The third serotype of the Dengue fever virus. Individuals infected with DENV-3 may experience symptoms similar to other serotypes, but the specific course of the illness may vary.
DENV-4: The fourth serotype of the Dengue fever virus. Infection with DENV-4 can cause symptoms of Dengue fever, including fever and joint pain. Severe cases may exhibit hemorrhagic symptoms.
Genome and Gene Annotation
RNA Elements
| CDS | Name | Function |
|---|---|---|
| POLY | 5'UTR | Non-canonical translation;vRNA synthesis |
| cHP | Translation initiation codon selection; viral viability | |
| 5'/ 3'UAR | vRNA cyclization; viral viability | |
| 5'/ 3'CS | vRNA cyclization;vRNA synthesis | |
| 3'UTR | Cap-dependent & non-canonical translation;vRNA synthesis | |
| VR | Translation;vRNA synthesis | |
| DB1/DB2 | Translation;vRNA synthesis | |
| 3'SL | Translation;vRNA synthesis | |
| POLY | C | vRNA packaging |
| prM | Prevention of premature fusion | |
| E | Receptor binding; fusion | |
| NS1 | Signal transduction | |
| NS2B | NS3 serine protease cofactor | |
| NS3 | Helicase; NTPase; 5'triphosphatase; serine protease | |
| NS4B | Inhibition of lFN signal transduction | |
| NS5 | RdRP; methyltransferase |
